Highly enantioselective synthesis of sultams via Pd-catalyzed hydrogenation.
نویسندگان
چکیده
Using pd(cf(3)co(2))2/(S,S)-f-Binaphane as the catalyst, an efficient enantioselective synthesis of sultams was developed via asymmetric hydrogenation of the corresponding cyclic imines with high enantioselectivities. The hydrogenation products can be conveniently transformed to chiral homoallylic amines without loss of enantioselectivity.
منابع مشابه
Highly Enantioselective Pd-Catalyzed Asymmetric Hydrogenation of N-Diphenylphosphinyl Ketimines Enantioselective Pd-Catalyzed Asymmetric Hydrogenation of N-Diphenylphosphinyl Ketimines
Transition-metal-catalyzed asymmetric synthesis is a powerful and commonly used method for preparing a wide range of enantiomerically pure compounds.1 Among organo-transition-metal compounds, Pd complexes have become indispensable tools for both common and stateof-the art organic synthesis.2 Although a large number of Pd-based catalytic systems have been developed for many kinds of reactions, P...
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ورودعنوان ژورنال:
- The Journal of organic chemistry
دوره 74 15 شماره
صفحات -
تاریخ انتشار 2009